The new series of three dimensional rotating mixer is a uniquely designed instruments which can mix samples by horizon, vertical or any angled rotation with a variety of sample tubes. Adjustaing the rotating frame can make the products either horizontally or vertically or between the angles of horizon and verticality to rotate. It is widely used in molecular hybridization, blood and verious samples requiring mixing. Its rotation speed is moderate. In addition, the two rotating frame on each side of the rotating roller can be adjusted in individually to meet different hybridmodes in one mixure. It is easily moved to different places, such as to test-bed, a refrigerator or an incubator. The shell and rotating panel of this instrument adopt a special design.